European Patent Application 0,101,418 (Kallstrand et al.) discloses what is said to be a controlled release pharmaceutical mixture which masks bad taste and increases stability of an active substance, characterized in that an encapsulated active substance is combined with a substance controlling the release of the active substance. The release-controlling substance is a carbohydrate or a carbohydrate-related material and microencapsulated theophylline is among the enumerated actives.
The objective of this study was first to develop and validate a stability-indicating HPLC-UV method for diazoxide and then to evaluate the stability of simple preparations of this drug compounded in Oral Mix and Oral Mix Sugar Free (SF). The suspensions were prepared from the bulk diazoxide powder as well as from diazoxide capsules. Oral Mix and Oral Mix SF are frequently used, dye-free, cherry flavoured oral suspending vehicles from Medisca Pharmaceutique Inc.
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Formulation concentration: dictates formulation composition. As the formula- tion active ingredient concentration increases, there is less room (%W-W) in the formulation for other components. Therefore it is necessary to select the most efficient wetting agent, dispersant, viscosity modifier. The lower the active in- gredient concentration in the formulation, the more "forgiving" the physical per-formance is to surfactant choice.
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A suspension of known concentration in CIPAC Standard Water is prepared, placed in a prescribed measuring cylinder at a constant temperature, and allowed to remain undisturbed for a specified time. The top 9-10ths are drawn off and the remaining 1-10th is then assayed either chemically, gravimetrically, or by solvent extraction, and the suspensibility calculated (Note 1).
If the formulation (e.g. WP) is packed in water soluble bags, the suspensibility tests should be performed in presence of dissolved water soluble bag material.
Suspension Concentrate (SC)
In comparison to OD formulations, where the continuous oil phase acts as an adjuvant, SC formulations can be considered less efficacious due to the continuous phase being water. To enhance the bioavailability of the active ingredient, adjuvants can be incorporated in SC formulations.
Stability Problems of Emulsion and Suspension
For regulatory approval, the milling technique must be well characterized and reproducible; the product must perform the same every time. A process which provides a poorly controlled PSD, or one which is not adequately characterized, can have great implications on the ultimate performance of the product, i.e., bioavailability.
A Study to Evaluate the Bioequivalence of an Oral Suspension Formulation, an Oral Solution Formulation, and the Marketed Tablet Formulation of Levofloxacin in Healthy Subjects
This article describes the formulation of dosage forms that are designed to be administered topically to the eye (principally the conjunctiva or the eyelid) for the treatment of primarily local disorders. Glaucoma, a disease of the interior of the eye, may also be treated using these dosage forms.
MetaDi and MetaDi Supreme Suspensions
Pastes are typically applied to a clean cloth by rotating the platen at approximately 50rpm and by placing the syringe tip about 2in out from the center of the platen. Start dispensing the paste onto the cloth, resulting in a spiral pattern, if the bead is raised, too much product has been dispensed.